Abstract
Polyacrylic acid (PAA)-derivatized Fe 3 O 4 magnetic nanoparticle (MNP) intended as a drug carrier were synthesized by two different approaches and studied for chemicophysical properties. PAA-MNP prepared by physical adsorption of PAA on pre-formed MNP showed better properties for covalent binding with a thrombolytic drug, recombinant tissue plasminogen activator (rtPA). The PAA-MNP-rtPA conjugate showed full retention of thrombolytic activity and is useful as a magnetically targeted drug carrier to improve clinical thrombolytic therapy.
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