Abstract
In this work, hydroxyapatite (HA) was modified by chelation of citric acid and Ca on the surface of HA, followed by the cross-linking between the hydroxyl groups of β-CD and citrate, and then the further in situ ring-opening polymerization (ROP) of l-lactide over the hydroxyl groups. The as-synthesized filler were characterized by FT-IR, XRD, TGA, and SEM. The results showed that HA was successfully modified with β-CD/citrate/PLA networks. The grafting amount of PLA-CD-HA-72 (β-CD/citrate/PLA) is up to 15.0 wt%, while the amount of PLA is 11.7 wt%. The modification of HA greatly improves the bioactivity. Comparing the synthesized samples, PLA-CD-HA-72 shows a better cell adhesion and higher viability to the mesenchymal stem cells (MSCs) of Wistar rat. Also the osteoinductivity of the PLA-CD-HA-72 is much higher than the others. Various composites are prepared by PLLA filled with HA, CD-HA and PLA-CD-HA-72, respectively. Among these composites, tensile strength of the PLA-CD-HA-72/PLLA with 2.5 wt% of filler reached 41.7 ± 2.2 MPa, which is much higher than that of the pure PLLA (31.7 ± 1.3MPa). The addition of the PLA-CD-HA-72 significantly improves the bioactivity and mechanical properties of the composite simultaneously. This kind of composite with good biocompatibility and mechanical properties is a good candidate for promising bioresorbable material.
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