Abstract
This study used electrospinning to produce a water-soluble polymeric nanofibrous film incorporated with quercetin. Scanning Electron Microscopy showed that the diameter of the nanofibers decreased from (670 ± 200) nm to (390 ± 90) nm as the amount of quercetin increased from 0% to 15%. The FTIR confirmed the presence of quercetin in the films and suggested the formation of physical interactions between the drug and the polymer. The XRD results confirmed the amorphous character of the nanofibers, and the loss of crystallinity by quercetin, due to the electrospinning process itself and the physical interactions with the polymer. The dissolution assays confirmed that the nanofibers and quercetin completely dissolved in the medium. This dissolution process reached equilibrium within 3 min. Although the material would not be effective as a controlled drug delivery device, it would be effective as a dissolvable film. The quick dissolution of both the drug and the matrix is attractive for the administration of quercetin because it would increase the bioavailability of the drug in the body, overcoming the limited dissolution of crystalline quercetin.
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