Abstract
AbstractThe reaction of (1R,2R)‐(–)‐1,2‐diaminocyclohexane (1) [DACH] with the aldehyde (1R)‐(–)‐myrtenal (2) in MeOH afforded the bidentate diimine ligand, (1R,2R)‐(–)‐N1,N2‐bis{(1R)‐(–)myrtenylidene}‐1,2‐diaminocyclohexane (3) in a high yield. Reduction of 3 using LiAlH4 led to the formation of the desired ligand (4) (1R,2R)‐(–)‐N1,N2‐bis{(1R)‐(–)myrtenyl}‐1,2‐diaminocyclohexane. Treatment of compound 4 with K2PtCl4 or K2PdCl4 yielded the corresponding platinum(II) and palladium(II) complexes, Pt‐5 and Pd‐6, respectively. The reaction of compound 3 with K2PtCl4 gave the diimine complex Pt‐7. The cytotoxic activity of the complexes Pt‐5, Pd‐6 and Pt‐7 was tested and compared to the approved drugs, cisplatin (Cis‐Pt) and oxaliplatin (Ox‐Pt). The complexes (Pt‐5, Pd‐6 and Pt‐7) inhibit L1210 cell line proliferation with an IC50 of 0.6, 4.2, and 0.7 μL, respectively as evidenced by measuring thymidine incorporation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Zeitschrift für anorganische und allgemeine Chemie
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
