Platelet Rich Fibrin (PRF) along with Coronally Repositioned Flap (CRF) compared with that of CRF alone in the management of isolated Miller class-I gingival recession defects: A non-randomized controlled clinical trial

Abstract

Periodontal plastic surgical techniques for root coverage are aimed to attain optimal results with less patient discomfort. Platelet-rich fibrin (PRF) containing a wide array of growth factors within fibrin network has shown beneficial results in healing of tissues. Study evaluated clinical effects of PRF along with Coronally Repositioned Flap (CRF), test group, and compared it with CRF alone, control group, in the treatment of Miller Class I gingival recession. From the subjects who attended the out-patients clinic, a non-randomized controlled clinical study was done on those who satisfied the inclusion criteria. In the control group 29 patients and in the test group 27 patients completed six months of study period. Clinical parameters pertaining to periodontal health and recession anatomy were recorded. Student t-test was used for intra and inter-group comparison. Multiple linear regression model was developed using three predictor variables. Mean root cover percentage in PRF and CRF groups were 96.25±6.89 and 94.59±10.31 respectively. PRF group showed reduction in gingival thickness at sixth month. Linear regression model showed a negative association of baseline gingival recession value with complete root coverage. CRF+PRF as well as CRF alone are equally effective in attaining >90% root coverage in Miller Class I gingival recession. The observed clinical benefits along with less invasive procedure involved in PRF technique, shows that it is a promising biomaterial in terms of objective appraisal. However, additional studies overcoming the limitations noticed are needed to ascertain the findings.