Abstract
BackgroundPlatelets play an essential role in both coagulation system and the host immune defenses against infection including community-acquired pneumonia (CAP). This work aimed to study the possibility of using platelet count as an additional criterion to predict the outcome of hospitalized patients with CAP.ResultsThis prospective cohort study included 250 patients hospitalized with CAP. According to platelet count at admission, 15 (6%) patients showed thrombocytopenia (group I) and 202 (80.8%) showed normal platelet count (group II), while 33 (13.2%) patients showed thrombocytosis (group III). CAP patients with thrombocytosis had more significant respiratory complications including lung abscess (p = 0.02), empyema (p < 0.001), and pleural effusion (p = 0.01). Severe sepsis and septic shock were significantly encountered among CAP patients with thrombocytopenia (p = 0.02 and 0.03, respectively). CAP patients with thrombocytopenia significantly needed mechanical ventilation either invasive (p = 0.017) or even non-invasive (p = 0.047). Both CAP patients with thrombocytopenia or thrombocytosis had significant 30 days readmission (p = 0.034) and significant 30 days mortality (p = 0.016) when compared to CAP patients with normal platelet count. Both thrombocytopenia (p = 0.012) and thrombocytosis (p = 0.029) were independent predictors of 30 days mortality among hospitalized patients with CAP.ConclusionsBoth thrombocytosis and thrombocytopenia are linked to adverse outcomes among hospitalized patients with CAP.
Highlights
Platelets play an essential role in both coagulation system and the host immune defenses against infection including community-acquired pneumonia (CAP)
This is consistent with the study carried out by Mirsaeidi et al who showed that 13% of CAP patients presented with thrombocytosis and 5% presented with thrombocytopenia [13]
Results of this study showed that CAP patients with thrombocytopenia and CAP patients with thrombocytosis had significant 30 days readmission and significant 30 days mortality when compared to CAP patients with normal platelet count
Summary
Platelets play an essential role in both coagulation system and the host immune defenses against infection including community-acquired pneumonia (CAP). This work aimed to study the possibility of using platelet count as an additional criterion to predict the outcome of hospitalized patients with CAP. Platelets are considered a cornerstone in the process of hemostasis They are well known to be an essential part of the immune response to various infectious agents [2]. Platelets are essential inflammatory cells that can be recruited to the site of inflammation and Thrombocytopenia is a well-known marker of adverse outcome in patients diagnosed with pneumonia, as decreased platelet count is linked to severe intravascular coagulation and severe sepsis [4]. We conducted this work to study the possibility of using platelet count as Ghoneim et al The Egyptian Journal of Bronchology (2020) 14:11 an additional criterion to predict the outcome of hospitalized patients with CAP
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