Abstract
SummaryAntibodies to PF4 were prepared in rabbits injected with highly purified human or pig PF4 preparations. Anti-human PF4 (AHPF4) caused aggregation of human platelets in plasma or in washed suspension. Anti-pig PF4 (APPF4) antibody caused aggregation of washed pig platelets. Slight cross reaction between the two species was observed. The aggregation was accompanied by the platelet release reaction, however, platelet lysis was not evident even on addition of complement. Aggregation could be blocked by prostaglandin E1, EDTA, potato apyrase, purified or crude PF4 and heparin. It is believed that platelet aggregation and the subsequent release reaction are triggered by the interaction of antibody with PF4 antigen on or in platelets.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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