Abstract
The studies on infections with Plasmodium cynomolgi recorded in this Supplement had their origins in the World War II search for drugs that at well-tolerated doses would effect radical cure of naturally acquired infections with Plasmodium vivax. At its onset, this search rested almost completely upon screening of new agents for activities against trophozoite-induced and sporozoite-induced infections with P. gallinaceum in chickens or P. cathemerium in canaries and trophozoite-induced infections with P. lophurae in ducks. Compounds that exhibited promising activities in these systems, and appropriate levels of tolerability in rats, dogs, and rhesus monkeys, were evaluated in human volunteers for capacities to prevent or cure infections induced with sporozoites of P. vivax. None of the agents selected on the basis of activities against the avian malarias exhibited such capabilities.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The American journal of tropical medicine and hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
