Abstract
We have studied the influence of sodium dodecyl sulfate (SDS) on plasminogen activator (PA) activity in culture supernatants derived from a human keratinocyte cell line (HaCaT) and in fluid aspirated from intraepithelial blisters of pemphigus vulgaris skin lesions. Addition of SDS to these specimens resulted in a marked increase of PA activity, as tested by chromogenic substrate assays. Stimulation of PA activity in the high-molecular-weight range after molecular sieve chromatography of HaCaT secretions or pemphigus vulgaris blister fluid suggested that SDS may activate PA activity from high-molecular-weight PA (PA/PAI?) complexes and that this mechanism could also be operative in vivo.
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