Abstract
The aim of the present study was to determine whether the following components of the fibrinolytic system are present in amniotic fluid: plasminogen, plasmin and α 2-antiplasmin, and plasmin–α 2-antiplasmin (PAP) complexes. The study group consisted of 30 healthy women giving birth at term; 10 nonpregnant women constituted a control group. Plasminogen and α 2-antiplasmin were studied by using an amidolytic method, and PAP by an ELISA method. The levels of plasminogen and α 2-antiplasmin in amniotic fluid are low, 1.57±0.82 and 6.80±3.09%, respectively, of the values in blood plasma. The PAP concentration in amniotic fluid (70.61±14.28 μg/l) was also lower than in blood plasma (247.19±111.39 μg/l). We concluded that in amniotic fluid plasminogen and α 2-antiplasmin are present, but at a concentration lower than in plasma. The presence of PAP in amniotic fluid is an evidence of two processes in the amniotic cavity: (i) plasmin generation, and (ii) plasmin inactivation by α 2-antiplasmin.
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