Abstract
Abstract Our previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza virus infection (IAV) is mediated via lymph node (LN) dendritic cells (DC) that express FasL and drive FasL:Fas (DC:T) induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC mediated elimination of IAV-specific CD8 T cells remain unknown. Here, we demonstrate that plasmacytoid DC (pDC) accumulate to greater numbers within the LN of lethal, compared sublethal, dose IAV infected mice. Further our findings show that lethal, but not sublethal dose, pDC drive elimination Fas+ CD8 T cells and that this elimination occurs in the absence of protective cognate IAV-peptide-MHCI:TCR interactions. Together our results suggest that pDC play a heretofore unknown role in limiting the CD8 T cell response therein increasing mortality during high dose IAV infections.
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