Abstract
The EDTA space and the plasma water volume of the whole animal and selected tissues were investigated with constant EDTA infusions of different duration in the rat. The calculated EDTA space increased with the duration of the infusion both in the whole animal and the tissues sampled. The plasma water volume remained constant, and therefore the calculated increase of the EDTA space suggests a slow intracellular accumulation of the tracer. As intracellular accumulation of EDTA increases with experimental time, it is necessary to use as short an experimental interval as possible to reduce this error when determining extracellular fluid volumes.
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