Abstract
BackgroundNesfatin-1 plays a role in the regulation of emotional states like depression. The aim of this study was to investigate the plasma nesfatin-1levels in Chinese patients with depression and healthy subjects, and to determine the possible association between the plasma nesfatin-1 level and the severity of depression.MethodsA total of 103 depressive patients and 32 healthy subjects were assessed. According to HAMD-17scores, 51, 18, and 34 patients were enrolled in the mild depression, moderate depression, and severe depression groups, respectively. Plasma nesfatin-1 levels were determined by the ELISA method. Differences between groups were compared and associations between plasma nesfatin-1 and other variables were analyzed.ResultsThe plasma nesfatin-1 was significantly positively correlated with HAMD-17 score (r = 0.651). Compared with healthy controls (8.11 ± 3.31 ng/mL), the plasma nesfatin-1 level significantly increased in patients with mild depression (11.17 ± 3.58 ng/mL), with moderate depression (16.33 ± 8.78 ng/mL), and with severe depression (27.65 ± 8.26 ng/mL) respectively. Plasma nesfatin-1 level (Odds ratio [OR] = 1.269) was an independent indicator for severe depression by multivariate logistic regression analysis.ConclusionThe plasma nesfatin-1 level is positively correlated with the severity of depression. Plasma nesfatin-1 level may be a potential indicator for depression severity.
Highlights
Nesfatin-1 plays a role in the regulation of emotional states like depression
The plasma nesfatin-1 level was significantly increased in depressive patients, most notably in patients with severe depression, compared to healthy controls
A positive correlation between plasma nesfatin-1and high-density lipoprotein cholesterol (HDL-C) in the depressive patients was observed in present study, and this relationship had been previously reported by Li et al [19] in the diabetic patients
Summary
Nesfatin-1 plays a role in the regulation of emotional states like depression. Major depressive disorder is the most common of serious psychiatric disorders and is recognized to be a high risk factor of suicide [1]. Evaluating the severity of depression is crucial for treatment [2]. Some previous studies have reported that nesfatin-1 played a role in integrating feeding, glucose homeostasis, and energy expenditure [6, 7]. The nesfatin-1 role in the regulation of emotional states including anxiety and stress was be found [8]. Nesfatin-1 can activate the HPA axis, the hyperactivity of which is proposed to be among the causal factors for triggering depressive
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