Abstract
At present, the molecular basis of vascular dementia (VaD) remains elusive. Comparative lipidomic analyses of VaD and ‘healthy’ age-matched controls may provide new insights to the possible vascular mechanisms in the pathogenesis of dementia. Plasma samples were collected from Bankstown-Lidcombe hospital with VaD patients (n=50) and normal controls (n=50). Lipids were extracted and liquid chromatography coupled to mass spectrometry was used to comprehensively analyze the plasma lipidome in VaD and normal controls. The abundance of lysophospholipids and sphingomyelin were significantly higher in VaD than in normal controls. Ceramides(Cer), cholesterol(CHE), phopholipids, glycerolipids for VaD were significantly lower in VaD than for normal controls. Phosphatidylcholine(PC) was not significantly different between the 2 groups, but the abundance of subgroup PC32, PC33, PC35, PC36, PC39, PC40, PC42 were significantly higher in VaD than in control, and other subgroups showed opposite results. Lipidomics can help to predict development of VaD.
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