Abstract
To further investigate neonatal thyroid function IR-TRH was studied by RIA after plasma chacoal extraction. TSH and IR-TRH were measured in paired maternal cord samples and in 40 min and 24 h old neonates. IR-TRH was higher in cord than in maternal plasma (p<0.001) and remained constant during the first 24h of life. No correlation with TSH was observed. IR-TRH was undetectable in 3 to 6 months old normal infants. In 2 anencephalics, cord IR-TRH was 15 and 8 pg/ml and no acute variation of TSH was observed during the first 2 h of life. In conclusion : High plasma IR-TRH was observed in human neonates at birth. Low values in anencephalic babies is in favour of the hypothalamic origin of this material.
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