Abstract
Plasma total homocysteine concentrations were measured in 8 healthy premenopausal women who, after a 9-d adjustment period with a vitamin B-6 intake of 1.60 mg/d, were marginally depleted of vitamin B-6 (0.45 mg/d) for 27 d, and then repleted with three levels of vitamin B-6 (1.26, 1.66 and 2.06 mg/d) for periods of 21, 21 and 14 days, respectively. Significant increases in plasma homocysteine concentrations were seen at the end of repletion periods 1 and 2, with a return to the adjustment concentration by the end of repletion period 3. Plasma homocysteine concentrations were negatively correlated with two measures of vitamin B-6 status, urinary 4-pyridoxic acid and plasma pyridoxal phosphate. Additional research is needed to determine whether plasma homocysteine concentration may be used as a functional, or indirect, measure of vitamin B-6 status.
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