Abstract
Plasma growth hormone (GH) responses, as measured by radioimmunoassy, were determined in individual rats following electrical stimulation of various hypothalamic and extrahypothalamic sites. In the hypothalamus, positive GH responses (rise in plasma GH levels > 10 μg/ml within IS min) occurred only with stimulation of the ventromedial or arcuate nucleus. Effective extrahypothalamic stimulation sites included the hippocampus, basolateral amygdala and mesencephalic interpeduncular nucleus. Reserpine administration (5 mg/kg; 24 hr before stimulation) was effective in preventing GH release induced by hippocampal stimulation but had no effect on ventromedial—arcuate—induced GH release. These results suggest that GH release may be induced by electrical stimulation either of the “final common pathway” in the medial basal hypothalamus or of certain extrahypothalamic structures with known connections to this region. (Endocrinology 91: 107, 1972)
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