Plasma concentration of creatine kinase-MB isoenzyme in dogs with intestinal form of canine parvovirus-2 infection

Abstract

Canine parvovirus (CPV) is the most dangerous and contagious virus that affects unprotected dogs. Two distinct parvoviruses are now known to infect dogs—the pathogenic CPV-2 and CPV-1 or the minute virus of canine. CPV-2, the causative agent of acute haemorrhagic enteritis and myocarditis in dogs, is one of the most important pathogenic viruses with high morbidity (100 %) and frequent mortality up to 10 % in adult dogs and 91 % in pups. The present investigation screened 45 clinical cases of canine gastroenteritis, and 10 dogs detected positive for canine parvovirus as confirmed by CPV-DNA amplification from feces using specific primers for CPV-2 by polymerase chain reaction were utilized for estimation of creatine kinase-MB isoenzyme (CK-MB) in plasma. Eight apparently healthy dogs were taken randomly to serve as the control group for CK-MB estimation in plasma. In conclusion, the findings of this study indicate that the CK-MB activity elevated with the severity of the disease in dogs infected with intestinal form of CPV-2.