Abstract
Levels of plasma 17-hydroxycorticosteroid hormone were obtained in 6 normal subjects during a 26-hr period, every 4 hr while awake and every 30 min during a night's sleep. An electroencephalogram was obtained during the sleep period. In all subjects a series of 3–4 peak elevations of the hormone occurred during the latter half of the night's sleep. A suggestive temporal relationship between the steroid elevations and the rapid eye movement (REM) sleep periods as noted. The role of the CNS in corticotrophin release and REM sleep activity is discussed.
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