Abstract
The current pharmacological agents advised for the management of diabetes as well as cardiovascular and hepatic diseases are subject to numerous studies for safety and efficacy. Therefore, it is worth looking into alternative therapeutic aids such as natural products of medicinal plants. By a broad review of in vitro and in vivo studies on the various dandelion, chicory, and mulberry extracts, this work highlights their bioactive compounds and therapeutic action when used as a prevention and management aid in public health such as diabetes, cardiovascular disease, and hepatic disorders like non-alcoholic steatohepatitis. Natural products of dandelion leaves and root extracts can suppress the development of liver cancer, decrease insulin resistance, and suppress total triglyceride and cholesterol levels. Recent studies on mulberry leaves extracts indicated that they could decrease palmitic acid-induced lipotoxicity, increase total cholesterol and bile acid excretion, improve superoxide dismutase expression, and improve insulin resistance. Chicory root extracts boost satiety, reverse insulin resistance, and augment lipid metabolism thanks to their contents in chicoric acid, chlorogenic acid, and polysaccharides. Taraxacum officinale L., Morus nigra L., and Cichorium intybus L. present hepatoprotective, anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic activities and are shown to be advantageous in the management of obesity, dyslipidemia, Type 2 diabetes, and non-alcoholic fatty liver diseases. These plants are commonly available in the European spontaneous flora and more attention could be paid to their natural products.
Highlights
There is a need for finding further alternative solutions to public health concerns
The proposed resolution is to focus our attention on plant biomolecules and natural products, which can be used in the development of functional products for preventing and managing public health concerns such as diabetes, hepatic disorders, and cardiovascular disease [1,2,3,4,5]
Weight loss seems to be the main non-invasive solution in ameliorating non-alcoholic steatohepatitis [27], patients suffering from non-alcoholic fatty liver disease (NAFLD) and NASH may as well benefit from positive results by consuming products rich in bioactive compounds with proven anti-inflammatory and antioxidant activities
Summary
There is a need for finding further alternative solutions to public health concerns. The proposed resolution is to focus our attention on plant biomolecules and natural products, which can be used in the development of functional products for preventing and managing public health concerns such as diabetes, hepatic disorders, and cardiovascular disease [1,2,3,4,5]. Weight loss seems to be the main non-invasive solution in ameliorating non-alcoholic steatohepatitis [27], patients suffering from NAFLD and NASH may as well benefit from positive results by consuming products rich in bioactive compounds with proven anti-inflammatory and antioxidant activities Such an example of an intensively studied beneficial compound is silymarin, which is a natural polyphenolic flavonoid of milk thistle (Silybum marianum) that addresses chronic inflammation diseases, insulin resistance, oxidative stress, hepatocellular protection, atherogenic dyslipidemia, and cardiovascular protection [28,29,30]. INS-1 cells in vitro, on a-glucosidase from baker’s yeast, rabbit liver, and small intestine in vitro, in carbohydrate metabolizing enzymes in vitro, in 3T3-L1 cell culture
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
