Abstract
The maternal plasma concentration at delivery and the umbilical venous plasma concentration of lignocaine have been determined following the use of the drug to produce epidural analgesia. Two modes of administering the drug have been examined: one in which a single epidural injection of lignocaine was given and one in which repeated injections were given to produce analgesia for a prolonged period. The results obtained show that lignocaine is rapidly transported from the epidural space to the foetal circulation and that it is present in the foetal circulation in high concentration, in relation to maternal plasma concentration, within 15 minutes after injection. The ratio of umbilical venous plasma concentration to maternal plasma concentration at delivery varied from 0.25 to 1.00. The maternal plasma concentration of lignocaine at delivery was directly related to the total dose of lignocaine given and bore no relation to the rate at which it was given.
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