Abstract
PL - 032 Physiological triggers involved in reduced slow myosin expression in disused postural muscle
Highlights
Our study was aimed to disclose the physiological triggers involved in the decline of Myh7 expression in postural muscle at the early stages of disuse state
After 24-h unloading we found a significant increase in the content of nuclear HDAC4 in the HS group, but in the HS+ β-guanidin-propionic acid (βGPA) group the content of nuclear HDAC4 didn’t differ from the control group. 24-h unloading resulted in a decrease in MyHCI(β) pre-mRNA and mRNA expression vs. the control group
We have shown that a 7-day unloading leads to a nitric oxide (NO) content decrease in the soleus muscle, and this effect is prevented by L-arginine administration
Summary
Our study was aimed to disclose the physiological triggers involved in the decline of Myh7 expression in postural muscle at the early stages of disuse state. We supposed that at the early stage of unloading (24 hours) it was the shift of the ATP/ADP/AMP balance (ATP accumulation due to muscle inactivation) to drive the Myh7 gene expression decline via AMP-activated protein kinase (AMPK) dephosphorylation and HDAC4 myonuclear import.
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