Abstract
The biological properties of the naturally occurring pituitary peptide α h 7–38-adrenocorticotropin (ACTH) have been investigated. α h 7–38-ACTH is devoid of steroidogenic activity but inhibits competitively ACTH-induced steroidogenesis in vitro as well as in vivo. The long-term actions of ACTH on normal and tumor adrenal cells in culture are also antagonized by α h 7–38-ACTH. The apparent K i for the inhibition of cyclic AMP production by α h 7–38-ACTH (301 ± 62 n m) was significantly higher than the apparent K i for the inhibition of corticosterone synthesis (21.6 ± 6.8 n m). Analysis of the inhibition of ACTH-induced steroidogenesis and cyclic AMP production in normal rat adrenocortical cells indicates that two separate receptors may be involved in mediating these responses.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
