Abstract
Piperacillin, a piperazine derivative of ampicillin, is an extended-spectrum penicillin that can be administered parenterally. A beta-lactam antibiotic, piperacillin is active against gram-positive cocci, including nonpenicillin resistant streptococcal, staphylococcal, and enterococcal species. However, it is rarely used for gram-positive infections since there are other more active agents available. It is effective against most gram-negative organisms, including Pseudomonas aeruginosa. Piperacillin is more active in vitro than any other extended-spectrum penicillin. Both gram-positive and gram negative anaerobic organisms are susceptible to piperacillin. Piperacillin is employed for the treatment of a variety of conditions including lower respiratory infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections. It is sometimes used in combination with tazobactam, a beta-lactamase inhibitor, for the eradication of some penicillin-resistant organisms.
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