PIN12 - Health Impact of Trivalent, Trivalent High Dose and Quadrivalent Influenza Vaccines In older adults In ontario, Canada

Abstract

BACKGROUND • Adults aged 65 years and older are known to have heightened susceptibility to influenza-related complications due to weakened immunity and reduced immune response to vaccines.1 • In 2000, Ontario province of Canada launched a free flu vaccination program and it has maintained a higher vaccination coverage rate in the elderly population than other provinces in Canada.2 • Two new vaccines, quadrivalent (QIV) and high dose inactivated influenza vaccines (HD), were developed to improve protection against influenza by boosting hemagglutinin (HA) antigen concentration and expanding the influenza B coverage; however, they are not widely used in the community and HD is still not yet approved in Canada.3 OBJECTIVES • This research aims to assess the health impact of the new vaccines in adults aged 65 years and older by routinely using HD or QIV instead of current trivalent inactivated vaccine (TIV) under Ontario’s Universal Influenza Immunization Program (UIIP) during one year. METHODS Population • The senior population is divided into three age group (6574 years, 75-84 years, and 85 years and older) with two health risk groups (high and low; HR, LR) to capture the variation in influenza-related complications. High risk for influenza-related complications was defined as the existence of any chronic conditions listed on PHAC, and the proportion of population in each risk group was estimated using Canadian Community Health Survey (CCHS) 2011/2012. Xiao (Angeline) Cheng1, Julie Roiz2, 1City University London, London, UK; 2Creativ-Ceutical Ltd, London, UK