Abstract
Ever-use of the pill had no adverse effect on the overall risk of cancer in the large cohort of British women participating in the Royal College of General Practitioners oral contraception study. Rather analyses of data reflecting as much as 36 years of observation indicate that ever-users of oral contraceptives had a 12% reduction in the risk of developing any cancer and a 29% reduction in the risk of developing cervical uterine or ovarian cancer. (Analyses of data from a subset of the cohort however revealed no association between ever-use and the risk of any cancer.) Long-term pill use was associated with elevated risks of some cancers and with reduced risks of others. Analyses of data from the U.S. Nurses Health Study another long-term cohort study confirm the inverse association between pill use and ovarian cancer risk; they also show that the risk of this disease is reduced among sterilized women and elevated among women who have used an IUD or are infertile. (excerpt)
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