Pico-ampere resolution current measurement circuit using Gm-C filter sigma-delta modulator for low-power nanopore DNA sequencing

Abstract

New generation DNA sequencers use an array of electrochemical cells equipped with nanopores, which produce pico-ampere current levels. Due to the large number of channels, low current levels and bandwidths in the order of a few kHz, in the design of these readout circuits, 2D arrays of in-channel, low noise and low power analog to digital converters are preferred. Previously many different sigma-delta modulators have been presented to convert the nanopore current signal into a digital code. Conventionally, the opamps required in these converters will eventually increase the power dissipation of each channel. In this paper a novel Gm-C filter based second order sigma-delta converter is proposed. In the given design, rather than relying on multiple opamps to achieve the necessary gain and noise performance, only a 4 transistor Gm block is used. Evaluations show that while the input referred noise remains close to previous methods, the power dissipation is considerably reduced. A prototype is also implemented to show the effectiveness of the approach. In a 180-nm design, an ENOB of 12.16 bits, RMS input referred noise of 0.2 pA at 10 kHz bandwidth and power dissipation of 8.27 μW is obtained per channel.