Abstract
Turmeric, a naturally occurring kitchen spice, possesses a wide range of medicinal properties. It has been reported to exhibit analgesic, anti-inflammatory, anti-bacterial, antifungal, antioxidant and wound healing properties. Yet, a detailed investigation is required for its screening against clinical isolates of multidrug resistant bacteria, so that it could be used as, cost effective, indigenous and readily available kitchen spice in crude form for the treatment of these bacterial infections at home. In current study, three fractions of ethyl acetate extracts of turmeric were screened against four multidrug resistant bacterial strains. Disc diffusion method was used to perform antibacterial activity and by calculation the Minimum Inhibitory Concentration (MIC). It was confirmed that all bacterial strains were highly sensitive towards all turmeric fractions. GCMS analysis of various fractions exhibited the presence of various flavonoids and polyphenols, their presence was further ascertained by chemical tests. It has been proposed that the synergistic effect of curcumin as well phenolics, crude extracts of turmeric showed promising antibacterial potential against multidrug resistant bacteria.Turmeric, a naturally occurring kitchen spice, possesses a wide range of medicinal properties. It has been reported to exhibit analgesic, anti-inflammatory, anti-bacterial, antifungal, antioxidant and wound healing properties. Yet, a detailed investigation is required for its screening against clinical isolates of multidrug resistant bacteria, so that it could be used as, cost effective, indigenous and readily available kitchen spice in crude form for the treatment of these bacterial infections at home. In current study, three fractions of ethyl acetate extracts of turmeric were screened against four multidrug resistant bacterial strains. Disc diffusion method was used to perform antibacterial activity and by calculation the Minimum Inhibitory Concentration (MIC). It was confirmed that all bacterial strains were highly sensitive towards all turmeric fractions. GCMS analysis of various fractions exhibited the presence of various flavonoids and polyphenols, their presence was further ascertained by chemical tests. It has been proposed that the synergistic effect of curcumin as well phenolics, crude extracts of turmeric showed promising antibacterial potential against multidrug resistant bacteria.
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