Abstract
BackgroundPhytochemical screening, antioxidant and antimicrobial activities of hexane, ethylacetate and methanol crude extracts of Acalypha ciliata plant was studied in this work. This plant according to folk medicine has been reported to be used for treatment of female sterility, dressing of sores and schistosomiasis.MethodsThe preliminary screening of the various extracts was carried out using standard methods and the results revealed the presence of flavonoids, tannins, alkaloids, reducing sugar, anthraquinones, resins and glycosides. The antimicrobial screening was carried out using the following organisms; Staphylococcus aureus, Eshericha coli, Bacillus subtilis, Pseudomonas aeruguinosa, Salmonella typhi, Klebsiellae pneumoniae, Candida albicans, Aspergillus niger, Penicillium notatum and Rhizopus stolonifer. The free radical scavenging capacity using hydrogen peroxide was equally determined to evaluate the antioxidant activities of the extracts.ResultsThe result obtained showed that Acalypha ciliata extracts have interesting pharmacological active compounds and antimicrobial effects, and as such could be used in ethno medicine for treatment of bacterial infections and ailments.ConclusionThe extracts of Acalypha ciliata plant contains notable chemical compounds that are responsible for its antioxidant and antimicrobial activity. Further investigations on the chemical compositionsand possible isolation of active ingredients would be carried out.
Highlights
Phytochemical screening, antioxidant and antimicrobial activities of hexane, ethylacetate and methanol crude extracts of Acalypha ciliata plant was studied in this work
The preliminary phytochemical screening revealed the presence of alkaloids, saponins, flavonoids, tannins, reducing sugar, phenols, glycosides and resins in some of the extracts as shown in the Table 1
This study has shown that the methanol extract of this plant possess high antimicrobial activities even at low concentration of 6.25 mg/mL; compared to the ethyl acetate and hexane extract placing it on a broad spectrum plane
Summary
Phytochemical screening, antioxidant and antimicrobial activities of hexane, ethylacetate and methanol crude extracts of Acalypha ciliata plant was studied in this work. This plant according to folk medicine has been reported to be used for treatment of female sterility, dressing of sores and schistosomiasis. Herbal and natural products of traditional medicine have been used by men since the advent of human race. Traditional healing in different cultures has a long history of ancestors creating primitive medicine during their struggle against natural calamities and diseases. While searching for food; the ancient humans discovered that some foods have specific properties of relieving or eliminating certain diseases and maintaining good health [2].
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