Abstract
The crude ethanolic extract of the seeds of Hyptis suaveolens was evaluated for its analgesic,antidiarrhoeal and cytotoxic activities. The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (69.7%, P < 0.001 and 60.6%, P < 0.001 for 500 and 250 mg/kg body weight,respectively), comparable to the standard drug diclofenac sodium. The extract also decreased the frequency of defecation and increased mean latent period significantly (P< 0.05) at the doses of 250 and 500 mg/kg body weight respectively compared with the control group. Moreover, it displayed considerable general toxicity towards brine shrimps. The LC50 value of the extract was 80 µg/ml which was comparable to that of standard drug chloramphenicol (43 µg/ml). All the results tend to justify the traditional uses of the seeds of Hyptis suaveolens.
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