Abstract
The increasing interest in developing potent non-toxic drugs in medicine is widening the opportunities for studying the usage of nanostructures in the treatment of various diseases. The present work reports a method for a facile and an eco-friendly synthesis of silver nanoparticles (AgNPs) using Terminalia chebula fruit extract (TCE). The obtained AgNPs was characterized by using different spectroscopic and microscopic techniques. The analysis of the results revealed that the as-obtained AgNPs have spherical morphology with an average diameter of 22 nm. Furthermore, the preliminary bioactivity evaluations revealed that the bio-conjugation of AgNPs, using TCE, significantly enhanced the antibacterial and anti-breast cancer potentials of the latter. The antibacterial activity of the as-prepared AgNPs showed that B. subtilis was more sensitive towards the AgNPs, followed by P. aeruginosa; while, E. coli and S. mutans showed comparatively minimal sensitivity toward the AgNPs. The IC50 values of TCE, AgNPs and TCE + AgNPs treatment of MCF-7 were found to be 17.53, 14.25 and 6.484 µg/mL, respectively. Therefore, it can be ascertained that the bio-conjugation may provide a headway with regard to the therapeutic employment of T. chebula, upon mechanistically understanding the basis of observed antibacterial and anticancer activities.
Highlights
IntroductionThe biosynthesis of nanoparticles has gained significant interest the field of biotechnology and nanotechnology with focused attention due to its proliferating need in the material synthesis
The biosynthesis of nanoparticles has gained significant interest the field of biotechnology and nanotechnology with focused attention due to its proliferating need in the material synthesis.Prominent efforts have been made in the synthesis of metal nanoparticles using plants and microorganisms
Transmission electron microscopy (TEM) images and Selected Area Electron Diffraction (SAED) pattern were recorded on JEOL 2100F FEG operating at 200 kV after casting a drop of AgNPs dispersion in ethanol over Cu grid (Jeol, Akishima, Tokyo, Japan)
Summary
The biosynthesis of nanoparticles has gained significant interest the field of biotechnology and nanotechnology with focused attention due to its proliferating need in the material synthesis. Prominent efforts have been made in the synthesis of metal nanoparticles using plants and microorganisms. AgNPs are very much suitable for biological imaging and sensing as they exhibit strong optical properties [4]. The AgNPs obtained using plants or plant extracts, using biological approaches, have become ecofriendly alternative tools against physical and chemical methods, thereby making them safer, and are preferred for human therapeutic use [5,6]. Terminalia chebula is the most widely used herb and commonly consumed traditional medicine of India [7]. It is well-documented traditional medicine to treat several diseases and infections [8]
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