Abstract
The interaction of 18 benzodiazepine (BDZs) derivatives with amino acids and with the membrane phospholipid di-palmitoylphosphatidylcholine (DPPC) was studied using charge-transfer reversed-phase chromatography and differential scanning calorimetry, respectively. A weak hydrophobic interaction was observed between the BDZs and Trp. Midazolam and medazepam were strongly bound to dicarboxylic amino acids, the strength of interaction being higher in ionic environment. BDZs modified the phase transition parameters of DPPC, indicating direct interaction. The enthalpy of the main transition of DPPC showed a nonlinear dependence on the specific hydrophobic surface area of BDZs, thus demonstrating the hydrophobic nature of the interaction.
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