Abstract
Six different carrier materials (250–425 μm) were used to prepare ordered mixtures of micronized griseofulvin. These mixtures and pure griseofulvin (agglomerates 500–710 μm) were measured on dissolution rate at sink conditions, using a paddle method at two rotational speeds. Highly soluble carrier materials gave an extremely fast dissolution, probably due to the fact that the drug was delivered as free, well-dispersed primary particles, after rapid dissolution of the carrier particles. The surface area utilized for dissolution was shown to be close to the external surface area of the primary particles, as measured by permeametry. Practically insoluble carriers, gave a limited increase in dissolution rate as compared to the griseofulvin agglomerates. This was explained mainly by an increased influence of diffusional transport, and to some extent by ,decrease in the surface area participating in dissolution. The use of a hydrophobic carrier, decreased the dissolution rate compared to griseofulvin agglomerates.
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