Abstract
Non-covalent binding of polymers to a mucin/epithelial surface has been demonstrated for a variety of polymers on a variety of biological surfaces. Structural features of the polymer which are important for bioadhesion have been explored using a copolymer of acrylic and methacrylic acid with variation in charge density and hydrophobicity of the molecules. Both charge density and hydrophobicity have been calculated and determined experimentally and both were related to bioadhesion of the polymer to the mucosal surface of fresh rabbit stomach. The more important parameter is charge density. In addition to structural features of the adhesive polymer, physical aspects such as degree and rate of hydration as well as particle size are important to bioadhesion, especially in an in vivo situation. Rates of hydration were determined by a labor intensive microscopic technique, as a function of pH and particle size. Lastly, intrinsic bioadhesion for a series of insoluble carboxylic acid polymers were determined. An estimated cohesive strength of the stomach glycoprotein was obtained from kinetic studies.
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