Abstract
A series of preliminary experiments was performed to screen several physical factors that might affect the subcoating process. On the basis of this preliminary screening, three variables were selected for further study: tablet density, pan speed, and pan load. The effect of each of these variables on the "roughness index" was studied. All three strongly influenced the roughness index value of the subcoated tablets. Two equations were developed—one showing the relationship between pan load and roughness index and the other showing the relationship between tablet density and roughness index.
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