Abstract
The tetramethyl-substituted amides of pimelamide, suberamide, azelamide, and sebacamide markedly enhance the solubility of glutethimide in aqueous solution. Partition studies, surface tension measurements, and light-scattering measurements strongly suggest that the amides are associating at infinitely dilute concentrations and further aggregation of these associated molecules occurs with the possible formation of micelles at concentrations slightly higher than that observed for surfactants. The CMC' s were identified at 0.41, 0.20, 0.031, and 0.11 M for pimelamide, suberamide, azelamide, and sebacamide, respectively. The solubility of glutethimide was increased significantly above the critical concentrations and, from the nature of the solubility curves, a micellar type of solubilization appears to be dominant.
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