Physical and biological study of Yttrium oxide/titanium oxide/carbon nanotube/polystyrene films for wound healing purpose

Abstract

Different contributions of dopants based on Yttrium oxide (Y2O3)/titanium(IV) oxide (TiO2)/carbon nanotube (CNT)/have been incorporated into the polymeric matrix of Polystyrene (PS). These films were fabricated in films due to their feasibility and low cost. The contact angle revealed that the dopants supported the hydrophilicity of the films that Y2O3/TiO2/CNT/PS represents the second highest wettability with (56.15 ± 6.35°) films, while Y2O3/PS film displays rough surface with the highest wettability with (32.5 ± 0.9°). we examined the impact of Y2O3/TiO2/CNT/PS composite on the viability of a human lung cell-line to better understand its biological behavior. Specifically, we measured cell viability as a means to assess the effect of the composite. The results revealed that at a concentration of 5000 μg/ml, the cell viability was measured to be 31.8 %. However, at a lower concentration of 2.4 μg/ml, the cell viability increased significantly to 117.9 %. These findings highlight a concentration-dependent relationship between the composite and the viability of the human lung cell-line. The observed cell viability exceeding 100 % indicates that the Y2O3/TiO2/CNT/PS composite scaffold had a positive effect on cell proliferation and generation. This suggests that the modified PS scaffold is conducive to cellular growth and can be considered safe for human use. The results imply that the composite scaffold promotes a favorable cellular environment, potentially supporting tissue regeneration and indicating its potential suitability for biomedical applications. The surface morphology shows that the topography of the films was changed clearly with the dopants of Yttrium oxide, titanium(IV) oxide and CNT components. The TiO2 granules implanted in the PS composition cause an increase in pore size to an average of 2.2 μm. Pore diameters ranging from 100 to 500 μm may enhance cell proliferation, while lower sizes lead to more stable implantable discs.