Physical and biological study of silver-vanadate/gadolinium oxide/cellulose acetate-based films for wound healing purposes

Abstract

In this study, cellulose acetate, silver-vanadate, and gadolinium trioxide wound dressing nano-films were investigated. Different weights of the aforementioned substances were chosen during manufacture to achieve a certain morphological appearance. The X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR), and Energy-dispersive X-ray spectroscopy (EDX) techniques were used to affirm the prepared composition. A scanning electron microscope (SEM) of silver-vanadate/gadolinium oxide/cellulose acetate film shows diminishing in pores size with growth in gadolinium trioxide grains. Porosity is the common feature in the imaged films which is essential for shaping vascularization and accelerating wound healing processes that the ability to transmit nutrients. Silver vanadate has shown an average grain size of 12.3 nm, while gadolinium oxide was 191 nm. On the other hand, the average pore size of the prepared membrane reached 324 nm. The greatest biocompatible potential films according to the contact angle values are gadolinium oxide @cellulose acetate and silver-vanadate/gadolinium oxide/cellulose acetate films, which have a contact angle of about 40.6°. The viability percentage of normal lung cells with 1.2 g/mL was 102.69%, whereas using 39 g/mL produced a viability rate of 88.27%. The range of refractive index variation is 1.88 to 4.62. The combined oxides/cellulose acetate preparation method results in considerable optical variations in the examined films. Consequently, this multifunctional wound dressing film investigated could be a promising and potential option biologically, i.e. for dressing for wound healing.