Photostability of Drugs and Drug Formulations

Abstract

Introduction: Photostability Testing of Drugs and Drug Formulations - Why and How? H. Hjorth Tonnesen Photophysical and Photochemical Aspects of Drug Stability, D.E. Moore Standardization of Kinetic Studies of Photodegradation Reactions, D.E. Moore Rationalizing the Photochemistry of Drugs, A. Albini and E. Fasani Technical Requirements and Equipment for Photostability Testing, J. Boxhammer and A. Schonlein Photostability Testing: Design and Interpretation of Tests on New Drug Substances and Dosage Forms, N.H. Anderson and S.J. Byard The Questions Most Frequently Asked, H. Hjorth Tonnesen and S.W. Baertschi Inconsistencies and Deficiencies Which Exist in the Current Official Regulations Concerning the Photolytic Degradation of Drugs, J.C. Hung Benefits and Adverse Effects from the Combination of Drugs and Light, J. Moan and P. Juzenas In Vitro Screening of the Photoreactivity of Antimalarials. A Test Case, H.Hjorth Tonnesen and S. Kristensen Screening of Dyes, Drugs and Dietary Supplements for Ocular Phototoxicity, J.E. Roberts Photochemical and Photophysical Methods Used in the Study of Drug Photoreactivity, S. Navaratnam Addressing the Problem of Light Instability During Formulation Development, D.R. Merrifield, P.L. Carter, D. Clapham, and F.D. Sanderson Photostability of Parenteral Products, S. Kristensen Photoactivated Drugs and Drug Formulations, J. Karlsen and H . Hjorth Tonnesen Formulation Approaches for Improving Solubility and its Impact on Drug Photostability, H.Hjorth Tonnesen Appendix 1: Useful Terms and Expressions in the Photoreactivity Testing of Drugs Appendix 2: Relevant Literature on the Photostability of Specific Drug Substances and Drug Formulations