Abstract
The novel supramolecular systems based on chlorine e 6 (Ce 6 ) are presented, and their optical absorption and fluorescence have been investigated. The influence of different excipients as poly-N-vinylpyrrolidone (PVP), polyethyleneglycol (PEG), bovine serum albumin (BSA), chitosan, Triton X-100 (TX-100) on spectral characteristics of these systems has been studied. The obtained spectral-fluorescence characteristics of Ce 6 -PVP, Ce 6 -PEG, Ce 6 -BSA, Ce 6 -TX-100 indicate disaggregation of chlorine e 6 molecules and their consecutive interaction with excipients in solutions and formation of molecular associates and molecular complexes. The system Ce 6 -chitosan is characterized by aggregation of pigments in solution that reduces photochemical activity of a photosensitizer. The fluorescence quantum yield j k of mentioned above supramolecular systems has been calculated. The results can be useful during the new method of controlled aggregation of photosensitizers as a part of supramolecular complexes development as well as for the purposes of new medicines of predictable photodynamic activity creation.
Highlights
Photodynamic therapy (PDT) is clinically used as a nonsurgical treatment in oncology, ophthalmology, dermatovenerology, and others, for various diseases, for example, cancers and bacterial cells
Supramolecular systems based on chlorine e6 (Ce6) (2 10-5 М) in various excipients were studied: poly-N-vinylpyrrolidone (PVP) - Ce6, polyethyleneglycol (PEG) - Ce6, Triton X-100 (TX-100) - Ce6, bovine serum albumin (BSA) - Ce6, chitosan Ce6
Obtained in this experiment optical absorption spectrum of Ce6 aqueous solution practically corresponds to the data of Ce6 optical absorption spectrum presented in [913]
Summary
Photodynamic therapy (PDT) is clinically used as a nonsurgical treatment in oncology, ophthalmology, dermatovenerology, and others, for various diseases, for example, cancers and bacterial cells. It is based on the use of a special chemical agent – photosensitizer (PS), which is accumulated in pathological target cells and initiated by laser light of an appropriate wavelength, corresponding photosensitizer absorption maxima. In real biological systems both mechanisms can take place. Their relative contribution to bioprocesses depends on the PS identity, a concentration and a nature of the oxidized reagents, a concentration of oxygen and some other factors
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