Abstract
ZnO@polymer core-shell nanoparticles with stable luminescence in aqueous solutions and tunable emission were synthesized by sol-gel method,studied in cytotoxicity tests towards HeLa cells and measured by laser confocal scanning microscope.The shell of such luminescent probes is a copolymer connected the ZnO core through coordination bonds,which contains an external hydrophilic layer of polymethacrylamide and an internal hydrophobic layer of polymethacrylate.Such design protected the ZnO cores from decomposition by aqueous solutions on one hand,and assured the highly dispersity and long-term stability in water on the other hand.Cytotoxicity measurements proved this material is biocompatible and suitable for biological labels.The results of the laser confocal imaging showed these nanoparticles could penetrate the membranes of HeLa cells and exhibited stable fluorescence in the cytoplasm.
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