Photodynamic therapy as a treatment option for skin cancer, developed on scars

Abstract

It is given a literature reference on the etiology, frequency and mechanisms of development, features of the clinical presentation and treatment options for skin cancer that has developed on scars. It is presented a detailed clinical observation of a patient with squamous cell skin cancer in the area of the right elbow joint, which occurred 67 years after the kerosene lamp burns of the skin of the right upper limb and the right half of the chest. The patient was initially treated with electron radiotherapy in the total focal dose 60 Gy with a partial effect, but after 10 months a relapse was diagnosed, for which multi-course photodynamic therapy was performed with a Photolon photosensitizer at a dose of 1.1 mg/kg; the way of light delivery was polypositional interstitial and distant, the laser radiation power density was 0.30 W/cm2, the laser radiation energy density was 200 J/cm2. The result of treatment is complete regression of the tumor, the patient was under regular observation without any signs of local, regional and distant metastasis. After 3 years, by the absence of signs of local relapse, the disease progression was diagnosed: metastatic lesion of the axillary lymph nodes on the right and multiple metastases in the lung tissue of both lungs. Treatment was performed: axillary lymphadenectomy on the right, targeted therapy with IgGl monoclonal antibodies directed against the epidermal growth factor receptor; on this background stabilization of the process was noted.