Abstract
This study investigated the photoactivity of four zinc phthalocyanines (PcZns) on a murine macrophage cell line infected with Leishmania amazonensis or Leishmania braziliensis. Infected and uninfected cells were incubated with PcZns at different concentrations (1-10μM) for 3h and then exposed to an LED device in continuous wave mode at 660nm with a fluency of 50J/cm(2) (25mV). Enzymatic activity was determined by MTT assay 24h after light treatment. The results demonstrated that all PcZns exhibited high photoactivity, particularly when used at 10μM. The photodynamic effects were different for uninfected cells versus parasite-infected cells and among the four PcZns. Uninfected cells were more sensitive to photoactivity than infected cells. Although PcZns photodynamic therapy provided promising results, further studies are necessary to better understand its mechanism of action in the treatment of leishmaniasis.
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