Abstract
The degradation of bionanomaterials is essential for medical applications of nanoformulations, but most inorganic-based delivery agents do not biodegrade at controllable rates. In this contribution, we describe the controllable plasmonic photocracking of gold@silica nanoparticles by tuning the power and wavelength of the laser irradiation, or by tuning the size of the encapsulated gold cores. Particles were literally broken to pieces or dissolved from the inside out upon laser excitation of the plasmonic cores. The photothermal cracking of silica, probably analogous to thermal fracturing in glass, was then harnessed to release cargo molecules from gold@silica@polycaprolactone nanovectors. This unique and controllable plasmonic photodegradation has implications for nanomedicine, photopatterning, and sensing applications.
Highlights
IntroductionAmong bioinorganic nanomaterials [5], mesoporous silica and organosilica nanoparticles (NPs) are promising hybrid nanomaterials for biomedical applications [6,7]
Engineering bioinorganic nanomaterials with controllable degradability rates is essential to prevent toxic bioaccumulation into the body after their diagnostic or therapeutic intended purposes [1,2,3,4].Among bioinorganic nanomaterials [5], mesoporous silica and organosilica nanoparticles (NPs) are promising hybrid nanomaterials for biomedical applications [6,7]
TEMgrowing images strongly implied by the gold insidecores out degradation strongly suggested internal suggested growing internal eventually lead to the cracking ofBesides, the particles
Summary
Among bioinorganic nanomaterials [5], mesoporous silica and organosilica nanoparticles (NPs) are promising hybrid nanomaterials for biomedical applications [6,7]. The controlled silicon chemistry and hybridization of silica NPs enables controlled surface modifications for various applications [6,23,24,25,26,27,28] including drug delivery [6,29,30,31,32] and medical diagnosis [33,34,35]. Plasmonic NPs are increasingly used as photothermal (PT) transducers for a wide variety of applications in colloidal and surface sciences [36,37,38,39,40,41,42,43].
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