Abstract
Protected oligonucleotides containing 3′-glycolate termini that are suitable for further elaboration are released from their solid phase supports using the o-nitrobenzyl intramolecular photochemical redox reaction. The yields of isolated oligonucleotides of varying sequence, ranging between 12 and 20 nucleotides long are between 45% and 79%, under conditions that have been previously shown to form less than 2% thymine•thymine photodimers.
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