Abstract
In this work, a polymeric supramolecular nanocage was assembled from a host–guest superamphiphile composed by a comb-like poly-cyclodextrin and azo-functionalized prodrug. The design principle and preparation procedures were interpreted, while in vitro and in vivo experiments were undertaken to prove the concept. The nanocage can achieve a long circulation and slow drug-release kinetics, but the drug-release will be greatly accelerated upon transcutaneous photo irradiation. Hopefully, this work is useful in illustrating the construction of controllable drug-delivery systems employing non-invasive triggers.
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