Abstract

Kinesin is an ATP driven dimeric motor protein carries cellular cargoes along microtubules. Azobenzene-dimaleimide (ABDM) is a bifunctional SH reactive photochromic compounds. We have previously demonstrated that ABDM was incorporated into the functional site of skeletal muscle myosin head (S1), and the global conformational change of S1 was induced by cis-trans isomerization of the cross-linked ABDM upon UV/VIS light irradiation, which may mimic the conformational change accompanied by energy transduction.

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