Abstract
Although the activation of AMP-activated protein kinase (AMPK) is well known to disturb cell migration, its mechanism remains largely unknown. Recently, we identified p64 protein as a new substrate of AMPK. Interestingly, vascular smooth muscle cells expressing the phosphomimetic p64 mutant displayed perturbed cell migration accompanied by actin cytoskeleton reorganization even in the absence of AMPK activation. Furthermore, Attenuation of actin network structures in cell periphery and dislocation of nucleation promoting factor (NPF) was seen in the cells expressing the phosphomimetic p64 mutant.
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