Abstract
Abstract Membrane phospholipids from malignant, benign and non-involved human breast tissues were extracted by chloroform-methanol (2:l) and analyzed by 31P MR spectroscopy at 202.4 MHz. Fourteen phospholipids were identified as constituents of the profiles obtained among the 52 specimens of the three groups: PC, PC plas LPC, LPC plas, PE, PE plas, LPE, PS, SPH, PI, CL, PG, PA and one uncharacterized resonance at 0.13 6. The relative P-lipid profile mole percentages of phosphorus and indices representing sums and ratios of individual or grouped P-lipids were computed and analyzed by one-way analysis of variance and were compared as simple and complex statistical contrasts. The analysis permitted differentiation among the three groups with the most poignant simple contrast being the relative absence of PA in normal tissues, followed by the significant mean mole percentage differences in PC plas between noninvolved (3.09 ± 0.41) and malignant (4.49 ± 0.23) tissues and between these same tissues in the value...
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