Abstract
AbstractAn efficient and practical phosphine‐catalyzed vicinal difunctionalization of β‐fluoroalkyl α,β‐enones with TMSN3 has been developed. Using dppb as the catalyst, the reaction worked efficiently to yield various β‐amino α‐diazocarbonyl compounds in high yields (up to 94 %). This work marks the first efficient construction of α‐diazocarbonyl compounds by phosphine catalysis. Meanwhile, the asymmetric variant induced by the nucleophilic bifunctional phosphine P4 led to various chiral fluoroalkylated β‐amino α‐diazocarbonyl compounds in high yields and enantioselectivity. NMR and ESI‐MS studies support the existence of the key reaction intermediates. In contrast, β‐azide carbonyl compounds would be furnished in good yields from β‐fluoroalkylated β,β‐disubstituted enones.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.